Efficacy of Autologous Intra-articular Platelet Rich Plasma Injection as a Biological Adjuvant in Early Primary Osteoarthrosis Knee—A Prospective Study

Abstract Introduction Classical characteristics of osteoarthrosis are reduction or loss articular cartilage, new bone formation, accompanied by synovial proliferation resulting in pain, joint function, and disability. Platelet rich plasma (PRP) has been used to provide stimulus for local regeneration healing. The present study was conducted with the aim evaluating clinical outcome efficacy injecting PRP intra-articularly early primary osterarthrosis knee. Objective Prospective injection knee respect stiffness, function quality life, short-term follow-up. Attempt made standardize protocol formulate PRP. Materials Methods Patients were divided into two groups: one treated autologous injections at 2 weeks interval second received symptomatic treatment physiotherapy. prospectively evaluated baseline then 1 month, 3 months, 6 months follow-up using visual analog scale (VAS) score, Western Ontario McMaster Universities osteoarthritis index (WOMAC) range movements. Results There VAS score group patients compared p-value <0.0001 which highly significant. a significant improvement WOMAC patients. Conclusion Autologous emerged as simple technique, sensitive procedure, cost-effective option. Administration intra-articular reduced significantly also observed who injection. doses found give adequate relief short term further long-term studies required.